Bifurc.net - Treatment of bifurcation lesions

 

 

 

 

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Dear EBC Friends,
The forthcoming European Bifurcation Club (EBC)meeting will take place in LISBON, Portugal on Friday 14th & Saturday 15th October 2011. The club’s main activity in its first year after the EBC meeting in Bordeaux (September 2005) focused on building up the meeting’s concept, producing its DVD, which was then distributed to all attendees, along with producing a consensus article for the Special Issue of the PCR Euro Intervention. In its second year, the EBC conducted its meeting in Rome (September 2006); it produced a DVD and carried out short technical meeting on QCA during PCR 2006, which led to a consensus proposal in Rome by Alexandra Lansky (Paper submitted to CCI). A consensus article has been published too in the EuroIntervention journal after the EBC meeting in Rome. An article was published in the CCI also early 2008 defining a new common language, result of a collective work. The 3rd meeting in Valencia, Spain saw some evident changes: The creation of workshops dedicated to essential anatomy and the function of the coronary vessels, the flow in bifurcations, new imaging techniques, thrombotic risk and also the creation of Industry workshops prepared by the Sponsors themselves as well as one investigators meeting. We had a 4th and 5th meeting in Prague and then Berlin, where the discussions in the wide field of bifurcation continued to be very active (not only for technical approach but also for the comprehension of anatomy, physiology and rheology of this complex lesion). The consensus paper will be published in the may issue of Eurointervention. We think that the club’s activity has motivated the realization of studies of a new generation, not limited to the comparison of simple techniques or complex in more or less defined groups but stricter which enable new ideas to develop and which will be the base of the EBC 2011 in Lisbon. We will have an update on the latest technical improvements that seem to contribute agreeable results with various strategies. We will also review comparisons of techniques well described in similar populations now increasingly reported or published. The treatment of the Distal Left Main trunk will benefit this year from the contribution of several important studies. We hope we will be able to present the first study realized with a Company grant under the auspices of the EBC. In the field of dedicated devices, we will only introduce new materials or/and new data. There will be time and space allocated to Sponsors to present their material. Please contact Alexandra: Alexandra@medi8events.com The final program of the Lisbon meeting is not finalized and we are open to suggestions from both doctors and industry. The very strong bonds forged during our six EBC meetings to date were mainly due to its informal aspect, which we still value and encourage. The invited delegates will also enjoy the chance to network at our final gala dinner. Continuing to explore nice and historical cities in Europe, we have chosen the destination of Lisbon and we will handpick approximately 150 Key Opinion Leaders in the Interventional Cardiology field. We significantly need your support to ensure we are able to build a successful meeting. Should you have any further questions, please do not hesitate to contact us. Many thanks for all your help and support and we are looking forward to hearing from you. Kind Regards, The EBC Committee: R. Albiero, A. Chiefo, O. Darremont, M. Ferenc, D. Hildick-Smith, J. Lassen, T. Lefèvre, Y. Louvard, M. Pan and G. Stankovic
EBC-2011
24/08/2011
EBC 2011 - Preliminary programme
download the provisional programme (24th august of 2011). Read the EBC's edito.
EBC-2011
24/08/2011
EBC 2010 Budapest program
Meeting Venues FRIDAY 22nd OCTOBER Investigator & Industry Pre-Meetings. Continental Hotel Zara, Hungary, 1074 Budapest, Dohány utca 42-44, Gold Sponsor Pre-Meeting & Plenary Sessions. Urania National Cinema Palace Auditorium, 1088 Budapest, Rákóczi út 21, SATURDAY 23 OCTOBER, Plenary Sessions. Urania National Cinema Palace Auditorium, 1088 Budapest, Rákóczi út 21. PLease download the EBC 2010 program - contact to : alexandra@medi8events.com
EBC webmaster
04/10/2010
EBC 2006 program - ROMA
EBC webmaster
04/10/2006
EBC 2008 program - PRAHA
EBC webmaster
04/10/2008
GUESTS FROM 31 COUNTRIES
Australy Ian MEREDITH Oestreich Manfred ZEHETGRUBER Belgium Bernard DE BRUYNE Victor LEGRAND Peter MORTIER Stefan VERHEYE William WIJNS Tom ADRIAENSSENS Christophe DUBOIS Bulgary Alexander DOGANOV Ivo PETROV Canada Raoul BONAN Vladimir DZAVIK China Shao-Liang CHEN Croatia Maja STROZZI Denmark Steffen HELQVIST Jens Flensted LASSEN Leif THUESEN France Paul BARRAGAN Jacques BERLAND Philippe BRENOT Philippe BRUNEL Didier CARRIE Damien COISNE Olivier DARREMONT Alain DIBIE Jean FAJADET Gérard FINET Patrice GUERIN Thierry LEFEVRE Jean-Louis LEYMARIE Yves LOUVARD Luc MAILLARD Laurent QUILLIET Karl ISAAZ Jacques MONSEGU United Kingdom Niall CURZEN Carlo DI MARIO Julian GUNN David HILDICK-SMITH Helen ROUTLEDGE Martyn THOMAS Germany Miroslaw FERENC Karl Eugen HAUPTMANN Stefan HOFFMANN P. KLEBER Josef LUDWIG Julinda MEHILLI Harald MUDRA Ralf MUELLER Peter RADKE Gerhard SCHULER Hans STOERGER Bernhard WITZENBICHLER Thomas ISCHINGER Greece Yiannis CHATZISISIS Ioannis IAKOVOU Gregory PAVLIDES George SIANOS Hungary Dezso APRO Gyorgy SZABO Imre UNGI Ireland Niall MULVIHILL Israel Abid ASSALI Italy Flavio AIROLDI Remo ALBIERO Antonio BARTORELLI Francesco BEDOGNI Francesco BURZOTTA Alaide CHIEFFO Antonio COLOMBO Gabriele DUBINI Alfredo GALASSI Francesco LAVARRA Alessandro LUALDI Imad SHEIBAN Japan Yutaka HIKICHI M MITSUDO Yoshinobu MURASATO Korea Hyeon-Cheom GWON Young-Hak KIM Kwon KOO Seung-Jung PARK Kuweit AL RASHDAN Lettonia Andrejs ERGLIS Netherlands Robbert DE WINTER Hans REIBER Patrick SERRUYS Pieter STELLA Willem VAN DER GIESSEN Norway Paul GUNNES Terje STEIGEN New Zeland John ORMISTON Poland Pawel BUSZMAN Dariusz DUDEK Robert GIL Maciej LESIAK Serbia Goran STANKOVIC Slovaquia Marko NOC Spain Celestina AMADOR Eulogio GARCIA Fina MAURI Alonso MEDINA Manuel PAN Jose Maria DE LA TORRE Antonio SERRA Switzerland Eric EECKHOUT Jean Jacques GOY Christian ROGUELOV Jean Francois SUMERLY Czech Republic Pavel CERVINKA Petr KALA Michael ZELIZKO USA Renu VIRMANI Maurice BUCHBINDER Marco COSTA Aaron KAPLAN Ghassan KASSAB Alexandra LANSKY Stan WILSON Finland Kari NIEMELA Matti NIEMELA
EBC webmaster
19/09/2009
Preliminary Program European Bifurcation CLub 2009
Friday, 16th October: Investigator and company meetings (Hotel) 11:00-13:00 Hotel Investigator meeting Blast (Volcano) 11:00-13:00 Hotel Capella meeting 13:00-14:00 Hotel Comittee meeting for EBC study David Hidick Smith 14:00-15:00 Cinema ABBOTT Pre-meeting 10:00-15:00 Pie medical hands on workshop Medis software hands on workshop Cordis bench tesing and virtual reality Welcome drink Hotel 15:30 - 17:30 : Hot news & Hot controversy 18:10 Ongoing EBC projects 18:20 Why I like this dedicated stent, devis, sofware... 20:00 Break cocktail 20:30-22:00 Case review session Saturday,17th October dowload the PDF file
EBC webmaster
19/09/2009
Results of coronary angioplasty in coronary bifurcation. Report of 61 cases
Hached L, Messaoudi H, Sahnoun M, Mallek S, Triki F, Frikha M, Grati Z, Hentati M, Kammoun S.
22/01/2004
Treatment of an ostial and a bifurcation lesion with a new directional atherectomy device.
Two cases of directional coronary atherectomy performed with a new 8 French monorail device for selective plaque excision are illustrated. This report underlines the technical characteristics of this new device, which allows the negotiation of complex coronary anatomy and emphasises the potential utility of directional coronary atherectomy in bifurcation and ostial lesions.
Favero L, Simpson JB, Reimers B.
22/08/2004
Influence of curvature dynamics on pulsatile coronary artery flow in a realistic bifurcation model.
The coronary arteries undergo large dynamic variations during each cardiac cycle due to their position on the beating heart. The local artery curvature varies significantly. In this study the influence of dynamic curvature on coronary artery hemodynamics is analyzed numerically. A realistic model of the bifurcation of the left anterior descending coronary artery and its first diagonal branch is curved by attaching it to the surface of a sphere with time-varying radius based on experimental dynamic curvature data. The description of the blood flow uses the time-dependent, three-dimensional, incompressible Navier-Stokes equations for Newtonian fluids, where the influence of the time-dependent flow domain is taken into account employing the Arbitrary Lagrangian-Eulerian technique. The inlet velocity profiles used in the computer simulation are physiologically realistic. The results show that the skewing of the axial velocity profiles near the branching site is mainly determined by the vessel branch; the bifurcating flow generally dominates the effect of curvature. The influence of curvature increases downstream of the branch. During systole, when curvature is greatest and high curvature variations appear, their effect on the flow patterns and the wall shear stress is dominated by the flow wave. Due to the smaller curvature changes during diastole, only minor effects of curvature variation on the high and relatively constant diastolic flow occur. The results demonstrate the importance of including physiologically realistic flow in the correct phase relationship with vessel motion when simulating coronary artery hemodynamics.
Prosi M, Perktold K, Ding Z, Friedman MH.
22/07/2005
Simultaneous kissing stents (SKS) technique for treating bifurcation lesions in medium-to-large size coronary arteries.
The treatment of bifurcation lesions (BLs) is associated with high procedural complication and restenosis rates. Two techniques of BL interventions were compared: the simultaneous kissing stents (SKS) technique, involving 2 stents, 1 in the main vessel and 1 in the side branch (n = 100), and the conventional stent strategy (CSS) technique, involving a stent in the main vessel and provisional stenting for the side branch (n = 100). In-hospital and 30-day major adverse cardiac events were greater in the CSS group, with significantly less procedure time with the SKS technique. The incidence of target lesion revascularization was 5% in the SKS group and 18% in the CSS group (p = 0.007). Therefore, the SKS technique seems to be rapid, safe, and effective for the treatment of medium- to large-size BLs, with a trend toward fewer acute complications and promising mid-term results.
Sharma SK, Choudhury A, Lee J, Kim MC, Fisher E, Steinheimer AM, Kini AS.
22/10/2004
Rapamycin-eluting stents for the treatment of bifurcated coronary lesions: a randomized comparison of a simple versus complex strategy.
BACKGROUND: Rapamycin-eluting stents (RES) have been shown to reduce restenosis in many types of lesions. However, the ideal strategy for the treatment of coronary bifurcated lesions has not been established to date. This randomized study compares 2 strategies for the RES treatment of bifurcation lesions: a simple approach (stenting the main vessel and balloon dilatation for the side branch [SB]) versus a complex approach (stents for both vessels). METHODS: To compare both strategies, a randomized study was conducted in 91 patients with true coronary bifurcation lesions. All patients received an RES at the main vessel, covering the SB. Patients from group A (n = 47) were assigned to balloon dilation of the involved SB (simple strategy); patients in group B (n = 44) were randomized to receive a second stent at the SB origin (complex strategy). There were no differences between groups regarding baseline clinical and angiographic data. RESULTS: Major adverse cardiac events occurred in 3 patients from group A (2 non-Q-wave myocardial infarctions and 1 target lesion revascularization). Six-month angiographic reevaluation was obtained in 80 patients (88%). Restenosis of the main vessel was observed in 1 (2%) patient from group A and in 4 (10%) from group B. Restenosis of the SB appeared in 2 (5%) patients from group A and in 6 (15%) from group B. CONCLUSIONS: Both strategies are effective in reducing the restenosis rate, with no differences in terms of clinical outcome. Elective SB stenting seems to provide no advantages over the simpler stent jail followed by SB balloon dilation.
Pan M, de Lezo JS, Medina A, Romero M, Segura J, Pavlovic D, Delgado A, Ojeda S, Melian F, Herrador
22/11/2005
Drug-eluting stents for coronary bifurcations: insights into the crush technique.
Sirolimus-eluting stents appear to reduce substantially restenosis following percutaneous coronary bifurcation intervention. The crush technique was devised to reduce restenosis further by improving stent and drug application to the side-branch ostium. We aimed to investigate the performance of drug-eluting stent (DES) platforms with the crush technique, to identify deployment pitfalls, and to clarify the best deployment strategies. Each stage of the crush technique was photographed in a bifurcation phantom. Simultaneous side- and main-branch dilatation (kissing balloons) fully expanded the stent in the side-branch ostium, widened the gaps between stent struts covering the side branch, and eliminated main-branch distortion. With side branches angled at > 70 degrees , sequential (side- then main-branch) inflations may be needed to achieve best results. Postdilatation of the main branch with a balloon of narrower diameter than the deploying balloon caused main-branch stent distortion. These principles applied to all the bifurcation strategies and stent designs tested.
Ormiston JA, Currie E, Webster MW, Kay P, Ruygrok PN, Stewart JT, Padgett RC, Panther MJ.
19/11/2004
Coronary bifurcation stenting. Current techniques, outcome and possible future developments.
Percutaneous treatment of coronary bifurcation lesions remained challenging in the stent era, with restenosis rates greater than 30% and no advantage from the routine use of kissing stents. Drug eluting stents (DES) have dramatically reduced the restenosis rates (RR) in the main vessel, but with conventional T-stenting double digits figures are still reported for the side-branch because of poor ostial coverage. The techniques of kissing stenting able to provide full lesion coverage (Culotte, V-stenting, Crush) have the potential to improve these results but the development of dedicated DES is probably needed to obtain consistently high procedural and long-term success.
Melikian N, Airoldi F, Di Mario C.
19/10/2004
Branch angle and flow into a symmetric bifurcation.
Arterial branches are found to be a major site for formation of arterial plaque. In this study, we investigate the role of the bifurcation angle on the flow into a symmetric bifurcation. Specially, how the changes in the bifurcation angle influences the distribution of axial wall shear in the bifurcation model. The flow in a range of branch opening half-angle of pi/25< or =theta< or =pi/4 are numerically simulated. The flow in the above models is calculated for the inlet flow Reynolds numbers of 250, 500, 1000, and 2000. It is found that at higher values of the opening angle of the bifurcation, the possibility and severity of flow separation at the appropriate wall location increases.
Tadjfar M.
19/08/2004
New approaches to ostial and bifurcation lesions.
Percutaneous coronary intervention of bifurcation lesions is associated with lower procedural success rates, and an increased subsequent rate of major adverse cardiac events and restenosis. Currently, an array of stenting possibilities suggests a rational approach to treat various bifurcation lesions with appropriate techniques. This is however seldom the case. The main problems of treating bifurcation lesions remain plaque shift leading to (threatened) side branch occlusion, and either too much or insufficient side branch ostial stent coverage predisposing to impaired side branch access or restenosis, respectively. This paper reviews the available technologies and their relative merits.
Hoye A, van der Giessen WJ.
19/12/2004
Balloon crush: treatment of bifurcation lesions using the crush stenting technique as adapted for transradial approach of percutaneous coronary intervention.
The recent advent of drug-eluting stents has allowed the crush stenting technique to be adopted, thus simplifying the treatment of bifurcation coronary artery lesions. However, this can only be achieved in 7 Fr or greater guiding catheters, hence precluding most transradial percutaneous coronary interventions that are usually undertaken using 6 Fr or less guiding catheters. We assessed the feasibility of balloon stent crush as a stepwise procedure in achieving bifurcation crush stenting in 6 Fr transradial percutaneous coronary interventions. Since it is not possible to place two stents through a 6 Fr guiding catheter, we have adapted the crush stenting technique by initially placing a stent in the side branch and a balloon in the main vessel. The side branch stent is then deployed against the main vessel balloon that is later inflated, crushing the side branch stent within the main vessel. The main vessel is then stented and the side branch recrossed for kissing inflations. Seven patients (five males; age range, 47-78 years) with bifurcation lesions were treated using the above-described technique without major complications. Balloon crush of the side branch stent were successfully achieved in all cases without balloon trapping. In six cases where side branch recrossing was attempted, all were successful and kissing balloon inflations were undertaken in five cases. We have demonstrated that the modified crush stenting technique is feasible and can be safely adapted for use in a 6 Fr transradial percutaneous coronary intervention approach.
Lim PO, Dzavik V.
19/12/2004
New bifurcation stenting technique: shunt stenting.
The optimal treatment of bifurcation lesions remains controversial. We describe a new technique we term shunt stenting. This technique incorporates both the new technology of drug-eluting stents and a novel procedure for optimizing the ostial side branch stent positioning. To date, early angiographic and clinical follow-up have been encouraging.
Prasan AM, Pitney MR, Ramsay D, Jepson NS, Friedman D, Taylor D, Giles RW.
19/07/2005